Dual Specificity Protein Phosphatase 1/6 Inhibitor

Chemical Properties

Boiling point	484.6±45.0 °C(Predicted)
Density	1.15±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMSO: 63 mg/mL (198.48 mM);Ethanol: 20 mg/mL (63.01 mM)
form	solid
pka	7.74±0.20(Predicted)
color	yellow
Water Solubility	Water: Insoluble
InChI	1S/C22H23NO/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2/b20-15-
InChIKey	XJDKPLZUXCIMIS-HKWRFOASSA-N
SMILES	N(C4CCCCC4)C1c2c(cccc2)C(=O)\C\1=C/c3ccccc3

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Animal Model:	Patient-derived xenograft (PDX) models (4-5-week-old female BALB/c nude mice)^[2]
Dosage:	35 mg/kg
Administration:	Intraperitoneal injection; every 7 days; for four weeks
Result:	Tumor weights in the PDX models treated plus CDDP were significantly suppressed compared with tumors from PDX model mice treated with either agent alone.