4-Bromophenoxytetrafluoroethanesulfonyl fluoride serves as a moderately reactive 4-bromophenoxytetrafluoroethanesulfonylation reagent. Fluoroalkylsulfonylation of the amine nitrogen greatly lowers the pKa value of the N-H and can be used to modulate the behaviour of the drug candidate or build additional molecular complexity around the highly acidic fluoroalkylsulfonamide nitrogen.
