Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) binds to cell membranes through hydrophobic interactions and electrostatic attraction. Cardiotoxin Analog (CTX) IV (6-12) is mainly embedded in the lipid bilayer through the N-terminal hydrophobic loop (amino acid sequence at positions 6-12), destroying the stability of the membrane structure, inducing membrane lipid disorder and cell lysis, and exhibiting hemolysis and cytotoxicity[1][2].
