m-PEG5-nitrile is a PEG linker containing a nitrile terminal group. The nitrile group can undergo hydrolysis, reduction and other reactions. The hydrophilic PEG spacer increases the solubility of compounds in aqueous media.
Uses
m-PEG5-nitrile is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
References
[1] Saifer MG, et al. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. DOI:10.1016/j.molimm.2013.07.014
