Norbinaltorphimine Dihydrochloride
Norbinaltorphimine Dihydrochloride
Norbinaltorphimine Dihydrochloride 性质
| 熔点 | >280 °C (decomp) |
|---|---|
| 储存条件 | Store at RT |
| 溶解度 | 温和加热下在水中的溶解度为 25 mM，在 DMSO 中的溶解度为 25 mM |
| 形态 | 粉末 |
| 颜色 | 浅黄至灰色 |
| InChIKey | JOJPJLHRMGPDPV-LZQROVCBSA-N |
| SMILES | Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13 |
Norbinaltorphimine Dihydrochloride 用途与合成方法
κ opioid receptor
Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.
Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.
Norbinaltorphimine Dihydrochloride 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-100903 | Norbinaltorphimine Dihydrochloride | 113158-34-2 | 5 mg | 950 |
| 2026-09-15 | HY-100903 | Norbinaltorphimine Dihydrochloride | 113158-34-2 | 10 mg | 1500 |
