151165-96-7
151165-96-7 性质
| 沸点 | 664.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.176±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 7.00±0.50(Predicted) |
151165-96-7 用途与合成方法
IBAT
S-8921 is an ileal Na + /bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [ 3 H] taurocholate dose-dependently in IBAT-COS cells, and the IC 50 value of S-8921 is 66±8 μM.
Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective.
