Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates. The regulatory M1 subunit is present throughout the cell division cycle, but downregulated in quiescent cells. Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer.
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