Ghrelin (rat) (acetyl) (trifluoroacetate salt)

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).1,2 Ghrelin requires an n-octanoyl modification at serine 3 for binding to the GH secretagogue receptor (GHS-R).3 Ghrelin (rat) (acetyl) is form of ghrelin that is acetylated at serine 3. Acetylated ghrelin is 20-fold less potent than n-octanoyl ghrelin in HEK-293 cells transfected with human GHS-R (IC50 = >2,000 nM; EC50 = 2,000 nM in an aequorin bioluminescence assay).4WARNING This product is not for human or veterinary use.

[1] MASAYASU KOJIMA. Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J]. Nature, 1999, 402 6762: 656-660. DOI: 10.1038/45230
[2] SUZANNE L. DICKSON . The role of the central ghrelin system in reward from food and chemical drugs[J]. Molecular and Cellular Endocrinology, 2011, 340 1: Pages 80-87. DOI: 10.1016/j.mce.2011.02.017
[3] RESH M D. Fatty acylation of proteins: The long and the short of it[J]. Progress in lipid research, 2016, 63: Pages 120-131. DOI: 10.1016/j.plipres.2016.05.002
[4] MARIA A. BEDNAREK. Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a⊥[J]. Journal of Medicinal Chemistry, 2000, 43 23: 4370-4376. DOI: 10.1021/jm0001727