Amylin (human) (trifluoroacetate salt)

Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.1 It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively.2 Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes.3 Amylin forms fibrils that react to thioflavin T and are organized in a cross-β arrangement of β-strands similar to amyloid-β (1-40) (Aβ40; Item No. 21617) and amyloid-β (1-42) (Aβ42; Item No. 20574) fibrils.4,5 Aggregated amylin (60 μM) decreases the viability of primary pancreatic islet cell cultures by 60%. It also inhibits electrically-stimulated contractions of guinea pig vas deferens (EC50 = 213 nM).6WARNING This product is not for human or veterinary use.

[1] LUTZ T A. Control of food intake and energy expenditure by amylin-therapeutic implications.[J]. International Journal of Obesity, 2009, 33 Suppl 1: S24-7. DOI: 10.1038/ijo.2009.13
[2] NAMBI AIYAR. Differential Calcitonin Gene-Related Peptide (CGRP) and Amylin Binding Sites in Nucleus Accumbens and Lung: Potential Models for Studying CGRP/Amylin Receptor Subtypes[J]. Journal of Neurochemistry, 1995, 65 3: 1131-1138. DOI: 10.1046/j.1471-4159.1995.65031131.x
[3] G J COOPER. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 23: 8628-8632. DOI: 10.1073/pnas.84.23.8628
[4] DAHABADA H J LOPES. Amyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP).[J]. The Journal of Biological Chemistry, 2004: 42803-42810. DOI: 10.1074/jbc.m406108200
[5] PING CAO  Daniel P R  Andisheh Abedini. Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology[J]. Current opinion in structural biology, 2013, 23 1: Pages 82-89. DOI: 10.1016/j.sbi.2012.11.003
[6] A. ELAINE TOMLINSON  David R P. Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens[J]. British Journal of Pharmacology, 1996, 117 6: 1362-1368. DOI: 10.1111/j.1476-5381.1996.tb16737.x