The gene LEPR (leptin receptor) is mapped to human chromosome 1p31. The neuroendocrine hormone, leptin, works through leptin receptor.
Leptin receptor (LEPR) is linked with risk of coronary artery disease. Mutation in LEPR is associated with low BMI (body mass index), increased leptin levels and some cancers. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.
