N-(Amino-PEG5)-N-bis(PEG4-acid)

N-(Amino-PEG5)-N-bis(PEG4-acid) is a aqueous soluble PEG linker with an amino group with two terminal carboxylic acids. The amino group is reactive with carboxylic acids, activated NHS esters. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids[1].

PEGs

[1] Pignatello, R., et al. New amphiphilic derivatives of poly(ethylene glycol) (PEG) as surface modifiers of colloidal drug carriers. III. Lipoamino acid conjugates with carboxy- and amino-PEG5000 polymers. Materials Science and Engineering: C, 2015.46, 470– DOI:10.1016/j.msec.2014.10.054