NSC-47924 (6638-24-0) is a potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM (IC50=19.35 μM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
1) Sierecki et al. (2010), Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase PHLPP by chemical and virtual screening; J. Med. Chem., 53 6899
2) Pesapane et al. (2015), Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion; Oncotarget, 6 18116
3) Samataro et al. (2016), The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LA cell surface localization and interaction with the cellular prion protein; Sci. Rep., 6 24457
