4-(Dimethylamino)-1-methylpyridinium is a monoquaternary pyridinium salt with anticholinesterase and antiproliferative activities.
1,2 It inhibits cholinesterase activity in rat brain homogenates with a K
d value of 33 μM and yeast choline kinase (ChoK) with an IC
50 value of 17 μM. 4-(Dimethylamino)-1-methylpyridinium also has antiproliferative activity against HT-29 colon cancer cells (IC
50 = 2 μM).
2
1. Jun, D., Paar, M., Binder, J., et al. Preparation and in vitro evaluation of monoquaternary inhibitors of brain cholinesterases Lett. Org. Chem. 6(6),500-503(2009).
2. Campos, J., del Carmen Nú?ez, M., Rodríguez, V., et al. LUMO energy of model compounds of bispyridinium compounds as an index for the inhibition of choline kinase Eur. J. Med. Chem. 36(3),215-225(2001).
