FMK-9A; FMK9A
FMK-9A; FMK9A 性质
| 沸点 | 724.6±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.241±0.06 g/cm3(Predicted) |
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | 二甲基亚砜：100 mg/ml（254.83 mM） |
| 酸度系数(pKa) | 12.82±0.46(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
FMK-9A; FMK9A 用途与合成方法
IC50: 80 nM (autophagin-1, FRET assay); 73 nM (autophagin-1, LRA assay)
ATG4B or autophagin-1 is a cysteine protease that cleaves ATG8 family proteins. ATG4B plays essential roles in the autophagosome formation and the autophagy pathway. FMK 9a shows strong inhibition of ATG4B, with IC 50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays, respectively. LC−MS/MS study indicates that FMK 9a forms an irreversible covalent bond with the more reactive thiol group of Cys74 located at the catalytic site of ATG4B and thus inactivates ATG4B proteolytic activity.
FMK 9a shows moderate solubility (LYSA: 41 μg/mL) and high human and mouse liver microsome clearances of 13.9 and 70 mL/kg per minute.
FMK-9A; FMK9A 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-100522 | FMK-9A; FMK9A | 1955550-51-2 | 5mg | 3500 |
| 2024-04-30 | HY-100522 | FMK-9A; FMK9A | 1955550-51-2 | 10mM * 1mLin DMSO | 3850 |
