1639895-85-4
1639895-85-4 性质
| 沸点 | 724.9±70.0 °C(Predicted) |
|---|---|
| 密度 | 2.604±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：26 mg/mL（49.17 mM 和升温） |
| 酸度系数(pKa) | 12.01±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
1639895-85-4 用途与合成方法
IC50: 0.33 µM (HIPK2)
Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival. TBID, displays toward HIPK2 unprecedented efficacy (IC 50 =0.33 µM) and selectivity (Gini coefficient 0.592 out of a panel of 76 kinases). The two other members of the HIPK family, HIPK1 and HIPK3, are also inhibited by TBID albeit less efficiently than HIPK2. The mode of action of TBID is competitive with respect to ATP, consistent with modelling. TBID interacts with the hinge region through hydrophobic interactions between Val 213, Val 261, Phe 277, Leu 280, Met 331, Ile 345, and the tetrabromine moiety, while the symmetric nitrogen atom at position 3 interacts with the catalytic Lys 228, thus playing a crucial role in the binding architecture.
1639895-85-4 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-02-08 | HY-100464 | 1639895-85-4 | 1639895-85-4 | 1mg | 1100 |
| 2025-02-08 | HY-100464 | 1639895-85-4 | 1639895-85-4 | 5mg | 2850 |
