m-PEG4-(CH2)3-methyl ester is PEG linker containing a methyl ester end group. Methyl ester can be hydrolyzed under strong basic condition. The hydrophilic PEG chain increases the solubility of the compound in aqueous media.
Uses
m-PEG4-CH2-methyl ester is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
