1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone inhibits the expression of MMP-3 and suppresses proinflammatory responses in mouse model with Parkinson''s disease. 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone is a neuroprotective agent.