Methyltetrazine-PEG5-Alkyne

Product NameMethyltetrazine-PEG5-Alkyne
CAS1802907-97-6
MFC20H26N4O5
MW402.44
EINECS
MOL File1802907-97-6.mol

Chemical Properties

Boiling point	568.5±60.0 °C(Predicted)
Density	1.176±0.06 g/cm3(Predicted)
storage temp.	2-8°C, stored under nitrogen
solubility	Soluble in DMSO, DCM, DMF
pka	1.67±0.10(Predicted)
form	Solid
color	Pink to red

Usage And Synthesis

Description

Methyltetrazine-PEG5-alkyne is a click chemistry bifunctional molecule containing an alkyne group and a hydrophilic PEG spacer which increases water-solubility. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule The alkynes can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages.

Uses

Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005