Ethylene Glycol 1,2-Bis(2-propynyl) Ether

Bis-propargyl-PEG2 is a homobifunctional PEG linker with two propargyl groups. The propargyl groups forms triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry.

Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005