Azido-PEG4-PFP ester is a click reagent containing an azide group and a PFP moiety. The azide group enables Click Chemistry. The PFP ester is can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules, comparing with NHS ester, PFP ester is more stable.. The hydrophilic PEG spacer adds to the water solubility of this reagent.
N3-PEG4-C2-Pfp ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG4-C2-Pfp ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
