SHZ-1 (326886-05-9) triggers cardiac mRNA and protein expression in a variety of embryonic and adult stem/progenitor cells including human mobilized peripheral blood mononuclear cells (M-PBMC).1?A lead compound for the discovery of drugs which promote myocardial repair/regeneration by activating cardiac differentiation in M-PBMC. Cell permeable.
2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide Benzenesulfonic Acid, is a sulfonylhydrazone that activates cardiac differentiation, inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations.
1) Sadek?et al. (2008),?Cardiogenic small molecules that enhanced myocardial repair by stem cells; Proc. Natl. Acad. Sci. USA,?105?6063
