2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE 性质
| 储存条件 | room temp |
|---|---|
| 溶解度 | H2O：可溶5mg/mL（澄清溶液） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | H2O: 5mg/mL (clear solution) |
| InChI | 1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H |
| InChIKey | WGWOQHWZXLGPNG-UHFFFAOYSA-N |
| SMILES | Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2 |
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE 用途与合成方法
P-glycoprotein
NSC23925 is a novel, selective and effective P-glycoprotein (Pgp) inhibitor. SKOV-3 cells with long-term exposure of 1 μM NSC23925 show stable growth in culture medium. NSC23925 specifically inhibits Pgp overexpression to prevent the emergence of paclitaxel resistance during paclitaxel treatment. NSC23925 reverses chemoresistance in a wide variety of tumor types where Multidrug resistance 1 (MDR1) is highly expressed. Maximal reversal of MDR is typically seen in NSC23925 doses between 0.5 and 1 µM. The IC 50 for NSC23925 is 8 µM in SKOV-3/SKOV-3 TR and 25 µM in OVCAR8/OVCAR8 TR cell lines, whereas the mean concentration of NSC23925 required for maximal reversal of resistance in SKOV-3 TR or OVCAR8 TR to cytotoxic drugs is 0.5 µM to 1 µM.
Both saline alone and NSC23925 alone treated tumors grow progressively. The usage of NSC23925 in paclitaxel chemotherapy significantly prolongs anticancer efficacy of paclitaxel.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 25 |
| 安全说明 | 45 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| 存储类别 | 6.1C - 可燃，急性毒性 类别3 毒性化合物或者引起慢性影响的化合物 |
| 危险性类别 | 急性毒性 类别3经口 |
2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-19626 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE | 858474-14-3 | 5mg | 1100 |
| 2026-09-15 | HY-19626 | 2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE | 858474-14-3 | 10mg | 1900 |
