This alkaloid is the major base found in Pachysandra terminalis Sieb. et Zucco
Like the other alkaloids present in this plant, it contains the pregnane skeleton.
It is dextrorotatory with [α]D + 24° (CHCI 3). It has two keto groups in the
molecule, one being present in a four-membered ring. Reduction with NaBH4
furnishes Pachystermine B (q.v.). The structure has been confirmed by the partial
synthesis of the alkaloid.
Kikuchi, Uyeo., Tetrahedron Lett., 3473 (1965)
Kikuchi, Uyeo., Chem. Pharm. Bull., 15, 549 (1967)
Partial synthesis:
Kikuchi et al., Tetrahedron Lett., 909 (1968)