Anti-TXN2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Thioredoxin, mitochondrial is a protein encoded by the TXN2 gene in humans. Thioredoxin 2 is a small redox protein th at plays an important role in cellular antioxidant defenses, as well as in the regulation of apoptosis. It possesses a dithiol-reducing enzymatic activity with mammalian thioredoxin reductase and NADPH. It is resistant to oxidation when compared to Trx1. It interacts with specific components of the mitochondrial respiratory chain and plays a crutial role in the regulation of the mitochondrial membrane potential. TXN2 is expressed in mitochondria and may directly protect it by preventing depolarization. Thioredoxin 2 interacts with mitochondrial transcription factor A (mtTFA) and facilitates its binding to damaged DNA. It also functions as an antioxidant.
