trimethyltin

trimethyltin

安全信息

毒性

An alkyltin compound occurring as an impurity in manufacturing processes. The oral LD50 in male rats is 10 mg/kg for the chloride salt. Trimethyltin is a neurotoxicant that causes neuronal damage to sensory neurons of both the central and peripheral nervous systems. Trimethyltin also causes damage to the limbic system, specifically the hippocampus. The mode of action is, at present, unknown, although in the hippocampus damage to the machinery associated with neurotransmission may be preferentially affected. Symptoms in humans include headaches, fatigue, weakness, loss of libido and motivation, sleep disturbances, depression, fits of rage, and seizures. There is no specific antidote; treatment is therefore symptomatic.