BH400 is an agonist of peroxisome proliferator-activated receptor α (PPARα) and an inhibitor of stimulator of interferon genes (STING; IC50 = 8.1 µM).1 It induces transactivation of PPARα in a reporter assay using THP-1 cells (EC50 = 1.2 µM). BH400 (10 µM) inhibits decreases in viability induced by 4-hydroxy nonenal (4-HNE; Item No. 32100) or hydrogen peroxide (H2O2) in 661W retinal ganglion cells. It prevents LPS-induced increases in phosphorylated TANK-binding kinase 1 (TBK1) and IL-6 levels and LPS-induced decreases in peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) levels in HMC3 microglial cells when used at a concentration of 10 µM.WARNING This product is not for human or veterinary use.
References
[1] HU B, CUI Y, LEE J J, et al. Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators[J]. ACS Medicinal Chemistry Letters, 2024, 14 1. DOI: 10.1021/acsmedchemlett.4c00153
