Allolithocholic Acid-d4

Allolithocholic acid-d4 is intended for use as an internal standard for the quantification of allolithocholic acid (Item No. 38158) by GC- or LC-MS. Allolithocholic acid is a secondary allomonohydroxy bile acid.1 It activates large-conductance calcium-activated potassium channels (BK/KCas; EC50 = 44.21 µM in Xenopus oocytes expressing the rat channel). Fecal levels of allolithocholic acid are increased in patients with colorectal cancer.2 Allolithocholic acid has also been found in the urine of infants with biliary atresia.3WARNING This product is not for human or veterinary use.

[1] ANNA N BUKIYA. Structural determinants of monohydroxylated bile acids to activate beta 1 subunit-containing BK channels.[J]. Journal of Lipid Research, 2008, 49 11: 2441-2451. DOI: 10.1194/jlr.m800286-jlr200
[2] TOMOAKI TADANO. Kinetic analysis of bile acids in the feces of colorectal cancer patients by gas chromatography-mass spectrometry (GC-MS).[J]. Rinsho byori. The Japanese journal of clinical pathology, 2007, 55 5: 417-427.
[3] I. MAKINO. Excretion of 3β-hydroxy-5-cholenoic and 3a-hydroxy-5a-cholanoic acids in urine of infants with biliary atresia[J]. FEBS Letters, 1971, 15 2: Pages 161-164. DOI: 10.1016/0014-5793(71)80047-9