Interleukin-12Rβ2 (IL-12Rβ2) is a type I cytokine receptor that is involved in immunity.1 It is composed of an N-terminal immunoglobulin-like (Ig-like) domain, five fibronectin type III domains, which facilitate cytokine binding, a transmembrane domain, and an intracellular domain that contains tyrosine phosphorylation motifs. IL-12Rβ2 is selectively expressed in T helper 1 (Th1) over Th2 cells.2 IL-12Rβ2 forms a heterodimer with IL-12Rβ1 to form the IL-12R, and forms a homodimer or heterodimers with gp130 or IL-27Rα to form receptors for IL-35, which all primarily act through the JAK/STAT pathway.3 It is the functional receptor for IL-12, as Th2 cells that express IL-12Rβ1 are unresponsive to IL-12 stimulation. Knockout of Il12rb2 (Il12rb2-/-) prevents increases in serum IFN-γ levels in IL-12- or LPS-stimulated mice.4 Il12rb2-/- mice exhibit increased disease severity in a model of relapse-remitting experimental autoimmune encephalomyelitis.5 SNPs in IL12RB2 are associated with chronic obstructive pulmonary disease (COPD).6 Cayman’s Interleukin-12Rβ2 Rabbit Monoclonal Antibody (Clone 093) can be used for ELISA.WARNING This product is not for human or veterinary use.
