Gly-Val-Ala-Pro-Gly (VGVAPG) is a peptide fragment of tropoelastin, containing a binding site to dermal
fibroblasts. VGVAPG has been shown to stimulate the growth of dermal fibroblasts by stimulating
a G protein coupled receptor on their cell surface. Unlike other signal peptides, VGVAPG has not been
shown to directly affect fibrillogenesis and collagen formation. Instead, it downregulates elastin expression
and plays an important regulatory role in ECM formation. VGVAPG has also been shown to affect
angiogenesis. VGVAPG increases the skin’s circulation and maintains its elasticity and structure to promote
younger looking skin.
