ISIS 14803

ISIS 14803 is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

[1] McHutchison JG, Patel K, Pockros P, et al. A phase I trial of an antisense inhibitor of hepatitis C virus (ISIS 14803), administered to chronic hepatitis C patients.?J Hepatol. 2006;44(1):88-96. doi:10.1016/j.jhep.2005.09.009 DOI:10.1016/j.jhep.2005.09.009