Benzamide, 3-[3-[acetyl[[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl]amino]-1-propyn-1-yl]-
Benzamide, 3-[3-[acetyl[[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl]amino]-1-propyn-1-yl]-
英文名称:Benzamide, 3-[3-[acetyl[[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl]amino]-1-propyn-1-yl]-
CAS号:2928480-72-0
分子式:C24H24ClN5O4
分子量:481.93
EINECS号:
Mol文件:2928480-72-0.mol
![Benzamide, 3-[3-[acetyl[[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl]amino]-1-propyn-1-yl]- 结构式](https://img.chemicalbook.com/CAS/20240320/GIF/2928480-72-0.gif)
Benzamide, 3-[3-[acetyl[[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl]amino]-1-propyn-1-yl]- 性质
| 沸点 | 664.0±55.0 °C(predicted) |
|---|---|
| 密度 | 1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
| 酸度系数(pKa) | 13.22±0.70(predicted) |
Benzamide, 3-[3-[acetyl[[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl]amino]-1-propyn-1-yl]- 用途与合成方法
II399 是一种有效和选择性的 NNMT 双底物抑制剂，包含非常规 SAM 模拟物，Ki 值为 5.9 nM。II399 对 NAM 表现出明显的竞争性抑制模式。II399 可以占据底物和辅因子结合口袋。
II399 有潜力用于癌症、代谢、心血管和神经退行性疾病的研究。
