CP 102

CP102 is an iron chelator.1,2 It decreases hepatic total non-heme and ferritin-stored iron levels in mice when administered in the drinking water at a concentration of 2 mg/ml.2

1.Dobbin, P.S., Hider, R.C., Hall, A.D., et al.Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potentialJ. Med. Chem.36(17)2448-2458(1993) 2.Smith, A.G., Clothier, B., Francis, J.E., et al.Protoporphyria induced by the orally active iron chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn miceBlood89(3)1045-1051(1997)