C12-113

C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice[1][2].

[1] Li J, Song J S, et al. YY1 regulates melanocyte development and function by cooperating with MITF[J]. PLoS genetics, 2012, 8(5): e1002688. DOI:10.1371/journal.pgen.1002688
[2] XUEXIANG HAN. Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines[J]. Nature nanotechnology, 2023, 18 9: 1105-1114. DOI: 10.1038/s41565-023-01404-4