This ATP and dATP analogue (FWfree-acid = 507.18 g/mol; CAS 3714-60-1), also known as 9-(5-O-(hydroxy(hydroxy(phosphonooxy) phosphinyl)phosphinyl)-b-D-arabinofuranosyl)-9H-purin-6-amine,Ara-ATP, adenine arabinoside 5’-triphosphate, and vidarabine 5’-triphosphate, is incorporated into viral DNA, thus inhibiting viral polymerase-mediated DNA synthesis via chain termination. Note: Some DNA polymerases are known to extend chains ending in the ara-nucleotide. Ara-ATP is available commercially for in vitro experimentation. Target(s): DNA primase; mRNA translocation; DNA-directed DNA polymerase; DNA polymerase a; DNA polymerase b; DNA polymerase g; ribonucleotide reductase; S-adenosylhomocysteine hydrolase; RNA polymerase; polynucleotide adenylyltransferase; GMP synthetase; lysyltRNA synthetase; leucyl-tRNA synthetase; adenylate cyclase; [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, possible alternative substrate; duck hepatitis B virus reverse transcriptase; RNA-directed DNA polymerase; DNA nucleotidyl exotransferase, or terminal deoxyribonucleotidyl transferase.
