Human;Mouse;Rat;Hamster;Monkey;Bovine
Growth factor receptor-binding protein 2 is an adaptor protein that is involved in RTK signal transduction. The SH2 domain of GRB2 binds to tyrosine phosphorylated proteins such as EGFR, IRS-1, Shc and Gab1. The SH3 domain of GRB2 associates with Sos, which stimulates the GTP binding activity of Ras, leading to the activation of the MAP kinase and other signaling pathways. Phosphorylation of Tyr209 of GRB2 by Bcr-Abl and EGFR abolishes its association with Sos and negatively regulates downstream signaling.
[1] Pawson, T. and Scott, J.D. (1997) Science 278, 2075-80.
[2] Li, S. et al. (2001) EMBO J 20, 6793-804.
