R(+)-SKF-81297 HYDROBROMIDE SELECTIVE D1 DOPAMINE

R(+)-SKF-81297 Hydrobromide is a dopamine D1 agonist.

R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:

• to test it effect on the spike firing in rat retinal ganglion cells
• in human embryonic kidney (HEK) 293T cells
• to test its inhibitory effect in microglial cells

SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.