基本属性 生物活性靶点体外研究体内研究 用途与合成方法 利血平盐酸盐 价格(试剂级) 供应商 供应信息 相关产品

利血平盐酸盐

利血平盐酸盐

中文名称:利血平盐酸盐
英文名称:reserpine hydrochloride
CAS号:16994-56-2
分子式:C33H41ClN2O9
分子量:645.13964
EINECS号:241-074-6
Mol文件:16994-56-2.mol
利血平盐酸盐 结构式

利血平盐酸盐 性质

储存条件 Inert atmosphere,Store in freezer, under -20°C
溶解度 DMSO 中≥25 mg/mL;不溶于水;温和加热和超声波下,乙醇中≥2.74 mg/mL
形态 固体
颜色 浅黄至黄色

利血平盐酸盐 用途与合成方法

Reserpine (hydrochloride) 是囊泡单胺转运蛋白 2 (VMAT2) 的抑制剂。

VMAT2

Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). Reserpine hydrochloride displays a significant on the density of dopamine D1 receptors (F 2,12 =8.81, p<0.01) in the rat striatum. The affinity (Kd) for the dopamine D1 and D2 receptors during withdrawal from acute and chronic administration of reserpine is not change. IC 50 values of 43.9 and 54.9 μM are obtained after 1 day of treatment with Reserpine hydrochloride in JB6 P+ and HepG2-C8 cells, respectively. Reserpine hydrochloride induces luciferase activity in a dose-dependent manner at concentrations ranging from 5 to 50 μM, and no significant induction is observed at concentrations lower than 5 μM. Results demonstrate that Reserpine hydrochloride (2.5 to 10 μM) also increases the protein expression of Nrf2, HO-1, and NQO1. Reserpine hydrochloride at concentrations of 2.5 to 10 μM decreases the mRNA expression of DNMT1, DNMT3a, and DNMT3b in a concentration-dependent manner in JB6 P+ cells after 7 days of treatment. Reserpine hydrochloride at 10 μM generates a significant difference for DNMT3a expression (p<0.05).

Withdrawal (48 h) from chronic (14-day) but not acute Reserpine hydrochloride administration in a dose of 0.2 mg/kg i.p. produces a significant reduction of the immobility time (F 2,18 =3.68, p<0.05), but increases the climbing time (F 2,18 =4.48, p<0.02), and does not change the swimming time (F 2,18 =1.78; NS) in the forced swim test (FST) in rats. Reserpine hydrochloride at a dose of 5 mg/kg body weight produces significant increase in the urinary excretion profile of vanillylmandelic acid (VMA) compare to control animals. The amount of 5-hydroxyindoleacetic acid (5-HIAA) excreted in animals treated with Reserpine is found to be more than in the control. Dose dependent hypotension is observed with Reserpine hydrochloride. Reserpine hydrochloride at doses of 0.5, 1, 5, 10 and 15 μg/kg produce significant (p<0.01) reduction in blood pressure compare to control.

利血平盐酸盐 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-N0480A 利血平盐酸盐 16994-56-2 100mg 500
2024-11-08 HY-N0480A 利血平盐酸盐 16994-56-2 10mM * 1mLin DMSO 550

利血平盐酸盐供应商 更多

广州爱纯医药科技有限公司
联系电话:020-39119399 18927568969
产品介绍:
中文名称:利血平盐酸盐
英文名称:Reserpine HCl
CAS:16994-56-2
纯度:98.0%
包装信息:1G; 25G; 1KG; 25KG
备注:品牌:StdSun | 提供定制合成服务(包括:小分子,药物杂质及医药中间体)
上海喀露蓝科技有限公司
联系电话:18149758185 18149758185
产品介绍:
英文名称:Reserpine hydrochloride
CAS:16994-56-2
纯度:98%
包装信息:1g;10g;100g
深圳市丽晶生化科技有限公司
联系电话:0755-0755-85201366 18938635012
产品介绍:
英文名称:Reserpine hydrochloride
CAS:16994-56-2
纯度:>98.0%
包装信息:10mg;100mg
备注:抑制剂进口标准品
成都圣美凯生物科技有限公司
联系电话:028-85157043 15882256948
产品介绍:
英文名称:Reserpine hydrochloride
CAS:16994-56-2
包装信息:MG G KG
备注:少量现货
北京迈瑞达科技有限公司
联系电话:010-82387566 18001021521;
产品介绍:
英文名称:Reserpine hydrochloride
CAS:16994-56-2
纯度:>=99%
包装信息:100mg

最新发布供应信息

化合物 Reserpine hydrochloride|T21772|TargetMol
TargetMol中国(陶术生物) 2024-09-29

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