Isotope labelled Diglycolic Acid (D446330), is a known metabolite of Diethylene Glycol (D444285), which acts as a nephrotoxic agent in human proximal renal tubule cells. Diglycolic Acid is also used in the synthesis of N-interlinked imipramines which show apoptotic activity against malignant cells as well as signs of combatting Burkitt’s lymphoma.
Crystallise it from hot water (7.5mL/g) by cooling to 0o with constant stirring. The crystals are filtered off on to a sintered-glass funnel and dried at 110o overnight. Its solubility in water is 2.6% (at 0o) and 20% (at 90o). [Beilstein 3 III 377, 3 IV 577.]
