SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1].
Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes
This phosphatidylinositol analogue (FWfree-acid = 598.76 g/mol), also known as SH-5, inhibits the proto-oncogenic serine/threonine kinase Akt (protein kinase B), inducing apoptosis. Specific inhibition of Akt by these compounds validates ligand design targeted to the PH domains of crucial signaling proteins, thus providing a unique class of possible cancer therapeutics.
[1] Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. DOI:
10.1016/j.bcp.2008.05.023
