Activity-regulated cytoskeleton-associated protein (ARC) is associated with synaptic plasticity and normal development in the central nervous system (CNS) induced by neuronal activity. Arc expression is tightly controlled by neuronal activity and its mRNA is rapidly localized to neuronal dendrites and spines where it undergoes local translation. Arc induction is required for late long-term potentiation (LTP) and memory consolidation, as well as LTP-induced cofilin phosphorylation and F-actin stabilization. Arc is known to regulate endocytosis of AMPA receptors mediated interaction with endophilin 3 and dynamin 2, notch signalling and spine morphology.
