WW-domain binding protein 2 is an adaptor protein first identified in a screen for proteins that interact with YAP1. WBP2 was subsequently shown to bind other WW domain-containing proteins, including TAZ and NEDD4-like ubiquitin-protein ligases. There is strong evidence for a conserved functional role for WBP2 in the Hippo kinase tumor suppressor pathway. WBP2 interaction is required for the oncogenic properties of TAZ in breast cancer cells and the growth-promoting properties of the YAP homolog Yorkie in Drosophila. In vitro studies have also suggested that WBP2 may act as a transcriptional co-activator of both estrogen and progesterone receptors; this interaction was shown to be dependent upon tyrosine phosphorylation of WBP2 by c-Src and c-Yes kinases.
[1] Chen, H.I. and Sudol, M. (1995) Proc Natl Acad Sci U S A 92, 7819-23.
[2] Chen, H.I. et al. (1997) J Biol Chem 272, 17070-7.
[3] McDonald, C.B. et al. (2011) Biochemistry 50, 9616-27.
[4] Chan, S.W. et al. (2011) Oncogene 30, 600-10.
[5] Jolliffe, C.N. et al. (2000) Biochem J 351 Pt 3, 557-65.
[6] Zhang, X. et al. (2011) Cell Death Differ 18, 1346-55.
[7] Dhananjayan, S.C. et al. (2006) Mol Endocrinol 20, 2343-54.
[8] Lim, S.K. et al. (2011) FASEB J 25, 3004-18.
