PCK2 encodes an isoform of phosphoenolpyruvate carboxykinase that is found in the mitochondria of renal and hepatic tissues. PEPCK is involved in gluconeogenesis, the process of generating glucose from non-carbohydrate substrates such as lactate and glycerol. PEPCK catalyzes the reaction whereby oxaloacetate becomes phosphoenolpyruvate, a rate limiting step in the metabolic process. The predominant function of PCK2 is to process the lactate that is continually produced by red blood cells in the liver and kidney.
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[2] Fischer, S. et al. (2010) Biol Reprod 83, 859-65.
