11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt

IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppressive activity. Inhibits LPS-induced proinflammatory cytokine and nitric oxide releasein vitro.1Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivityin vivo.2

IQ 1S is a JNK inhibitor which inhibits LPS-induced proinflammatory.

JNK3: 87 nM (Kd); JNK2: 360 nM (Kd); JNK1: 390 nM (Kd); PI3Kγ: 1.2 μM (Kd); CK1δ: 1.4 μM (Kd); MKNK2: 1.8 μM (Kd)

[1] IGOR A SCHEPETKIN. Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors.[J]. Molecular Pharmacology, 2012, 81 6: 832-845. DOI:10.1124/mol.111.077446
[2] IGOR A SCHEPETKIN. Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 353 3: 505-516. DOI:10.1124/jpet.114.220251