JND3229

Chemical Properties

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Animal Model:	BALB/c mice (bearing established BaF3-EGFR19D/T790M/C797S mouse xenograft tumors model)^[1].
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; twice daily for 10 days.
Result:	Caused an obvious suppression of tumor growth with a Tumor Growth Inhibition (TGI) value of 42.2%. Showed well tolerance without obvious body weight loss or other obvious toxic sign in the treated animals. Significantly decreased the level of phosphorylated EGFR (p-EGFR) tin the tumor tissues.