Pregnanediol-3-Glucuronide (PDG) ELISA Kit

Pregnanediol-3-Glucuronide (5β-pregnane-3α,20α-diol-3α-glucuronide, PDG or P3G) is the major metabolite of progesterone, an endogenous steroid and the most important member of the class of steroid hormones known as progestogens. Progesterone is important in a variety of biological functions such as preparing the endometrium for implantation, maintaining pregnancy, differentiating breast tissue, and promoting normal development of neurons in the brain as a neuro steroid. Low progesterone levels are linked to chronic anovulation which is reported to be associated with female infertility, breast cancer and endometrial cancer.Levels of PDG in the urine correlate highly to levels of progesterone measured in the serum. PDG analysis may be used as a non-invasive method to indirectly measure progesterone and therefore might be used as a biomarker for luteal activity, ovarian cancer, and a variety of other biological disorders.

[1] A KASSAM. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm.[J]. Environmental Health Perspectives, 1996, 104 4: 408-413. DOI: 10.1289/ehp.96104408
[2] WIEBE J P. Progesterone metabolites in breast cancer.[J]. Endocrine-related cancer, 2006, 13 3: 717-738. DOI: 10.1677/erc.1.01010
[3] KATHLEEN A O’CONNOR. Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population research.[J]. Clinical chemistry, 2003, 49 7: 1139-1148. DOI: 10.1373/49.7.1139
[4] C J MUNRO. Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay.[J]. Clinical chemistry, 1991, 37 6: 838-844.
[5] JELENA M PAVLOVI. Sex hormones in women with and without migraine: Evidence of migraine-specific hormone profiles.[J]. Neurology, 2016, 87 1: 49-56. DOI: 10.1212/wnl.0000000000002798
[6] ANNEKATRIN LUKANOVA  Rudolf K. Endogenous hormones and ovarian cancer: epidemiology and current hypotheses.[J]. Cancer Epidemiology Biomarkers & Prevention, 2005, 14 1: 98-107.
[7] J JULIE KIM  Serdar E B  Takeshi Kurita. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.[J]. ACS Omega, 2013: 130-162. DOI: 10.1210/er.2012-1043