C18 Ganglioside GM1-d3 (d18:1/18:0-d3) (ammonium salt)

C18 Ganglioside GM1-d3 (d18:1/18:0-d3) is intended for use as an internal standard for the quantification of C18 ganglioside GM1. Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2 C18 Ganglioside GM1 is found in the brain, primarily in the piriform cortex, amygdala nucleus, striatum, and hippocampal CA1 region.3 The ratio of C18 ganglioside GM1 (d20:1/18:0) to C18 ganglioside GM1 is decreased in the outer molecular layer of the hippocampal dentate gyrus in postmortem tissue from patients with Alzheimer’s disease.4 As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 2050]WARNING This product is not for human or veterinary use.

[1] KOLTER T. Ganglioside biochemistry.[J]. ISRN biochemistry, 2012, 2012: 506160. DOI: 10.5402/2012/506160
[2] MOCCHETTI I. Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins.[J]. ACS Applied Nano Materials, 2005: 2283-2294. DOI: 10.1007/s00018-005-5188-y
[3] DOUGLAS A ANDRES. Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging.[J]. ACS Applied Materials & Interfaces, 2020: 1537. DOI: 10.1194/jlr.ilr120000870
[4] WAKAKO HIRANO-SAKAMAKI . Alzheimer’s disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus[J]. FEBS Letters, 2015, 589 23: Pages 3611-3616. DOI: 10.1016/j.febslet.2015.09.033