Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ).
1,2 DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3
via peptidases.
1 PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma.
3 It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.
4
1. Rodriguez, A.R., and Spur, B.W. Total synthesis of pro-resolving and tissue-regenerative protectin sulfido-conjugates Tetrahedron Lett. 56(42),5811-5815(2015).
2. Aursnes, M., Tungen, J.E., Colas, R.A., et al. Synthesis of the 16S,17S-epoxyprotectin intermediate in the biosynthesis of protectins by human macrophages J. Nat. Prod. 8(12),2924-2931(2015).
3. Serhan, C.N., Dalli, J.P., and Chiang, N. Oxylipin-peptide conjugated mediators that promote resolution of infection, organ protection and tissue regeneration US20170258806 A1,(2014).
4. Ramon, S., Dalli, J., Sanger, J.M., et al. The protectin PCTR1 is produced by human M2 macrophages and enhances resolution of infectious inflammation Am. J. Pathol. 186(4),962-973(2016).
