(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid (DHA; ) that is produced
via oxidation by cytochrome P450 epoxygenases.
1 Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.
2
1. VanRollins, M., Baker, R.C., Sprecher, H., et al. Oxidation of docosahexaenoic acid by rat liver microsomes J. Biol. Chem. 259(9),5776-5783(1984).
2. VanRollins, M. Epoxygenase metabolites of docosahexaenoic and eicosapentaenoic acids inhibit platelet aggregation at concentrations below those affecting thromboxane synthesis J. Pharmacol. Exp. Ther. 274(2),798-804(1995).
