(E,E)-2-[(Dihydroxyphosphinyl)methyl]-3-oxo-3-[(3,7,11-trimethyl-2,6,10-dodecatrienyl)-amino]propanoic acid, 3Na

A highly selective and potent inhibitor of Ras farnesyltransferase (IC₅₀ = 83 nM). Inhibits geranylgeranyltransferase I (IC₅₀ = 26 µM) and II (IC₅₀ = 47 µM) at much higher concentrations.
Potent and highly selective inhibitor of farnesyltransferase (FTase; IC₅₀ = 83 nM). Inhibits geranylgeranyltransferase (GGTase) I and II at much higher concentrations (IC₅₀ = 26 µM and 47 µM for GGTase I and II, respectively).
The FPT Inhibitor I controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

Primary Target
Farnesyltransferase (Ftase)', 'Product does not compete with ATP.', 'Target IC50: 83 nM against Ftase