SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats[2].
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs[3].
| Animal Model: | Male Wistar rats (5 weeks) are subjected to coronary artery ligature[2]. |
| Dosage: | 0.2, 2, 20 mg/kg. |
| Administration: | A single i.p. injection. |
| Result: | Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg
Did not affect other contractile parameters.
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